Table 4.
Serum 25(OH)D and fibroid loss in 539a participants in tne Study of Environment, Lifestyle & Fibroids, Detroit, Michigan, 2010–2018
| Categories of 25(OH)D ng/ml | Intervals with Loss / Eligible Intervals (%) | Risk Ratio (95% Confidence Interval) | |
|---|---|---|---|
| Minimally Adjustedb | Fully Adjustedc | ||
| <12 | 71/319 (22.3) | REF | REF |
| 12–<20 | 97/406 (23.9) | 1.04 (0.80, 1.35) | 1.06 (0.81, 1.38) |
| 20–<30 | 56/217 (25.8) | 1.04 (0.76, 1.42) | 1.14 (0.83, 1.57) |
| >30 | 24/77 (31.2) | 1.29 (0.88, 1.88) | 1.40 (0.95, 2.06) |
| <20 | 168/725 (23.2) | REF | REF |
| ≥20 | 80/294 (27.2) | 1.08 (0.86, 1.36) | 1.17 (0.92, 1.48) |
| <30 | 224/942 (23.8) | REF | REF |
| ≥30 | 24/77 (31.2) | 1.26 (0.90, 1.75) | 1.32 (0.95, 1.83) |
Note: 25(OH)D, 25-hydroxyvitamin D; HS/GED, High School/General Education Diploma.
Loss analyses were conducted among 539 participants with 1–4 prevalent fibroids at the beginning of an observed interval. This includes participants with fibroids at enrollment and those who develop incident fibroids.
Minimally adjusted model includes age (continuous), months between visits (continuous), number of fibroids (1, 2, ≥3) and volume of largest fibroid (<0.5 cm3, 0.5–4.19 cm3, 4.2–14.0 cm3, ≥14.1 cm3).
Fully adjusted model also includes years since last birth (<4 years, ≥4 years ago including no birth), years since last use of injection contraceptive (<2 years, ≥2 years/never), body mass index kg/m2 (<25, 25–<30, 30–<35, 35–<40, ≥40), education (HS/GED or less, >HS/GED). Four observations excluded from analyses due to missing data on at least one covariate.