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. 2022 Sep 2;71(2):187–204. doi: 10.1002/glia.24266

FIGURE 12.

FIGURE 12

Loss of oligodendrocyte ErbB signaling by ErbB3 KO leads to reduced A1 MBP and PV mRNA levels and PV+ cell density. (a) Reduced ErbB3 (n = 7; p = .0230) and MBP (n = 7; p = .0175) mRNA levels in A1 after oligodendrocyte‐specific ErbB3 KO (PLP/creERT::ErbB3fl/fl). (b) Relative mRNA expression for parvalbumin (PV), vasoactive intestinal peptide (VIP) and somatostatin (SST) in the A1 of WT (black) and PLP/creERT::ErbB3fl/fl (blue) mice. PV mRNA levels are reduced in A1 of PLP/creERT::ErbB3fl/fl mice (n = 6–7; p = .0093). No changes are observed in VIP (p = .3176) and STT (p = .62) mRNA expression. (c) A1 PV mRNA levels correlate with MBP mRNA levels (WT: black dots, PLP/creERT::ErbB3fl/fl: blue dots; Pearson's correlation r = 0.7787; p = .001). (d) Representative photomicrographs of A1 sections from WT and PLP/creERT::ErbB3fl/fl mice showing PV+ cells (green). Scale bar: 100 μm. (e) A1 PV+ cell density is reduced in PLP/creERT::ErbB3fl/fl mice (n = 5–6; p = .0043). Mann–Whitney test was performed. Data are expressed as mean ± SEM.