Table 2 –
Effects of Ethanol on Gating Rate Constants
kf+ | kf− | ks+ | ks− | o+ | o− | |
---|---|---|---|---|---|---|
| ||||||
GluN2A | ||||||
Control | 4110 ± 207 | 2860 ± 379 | 423 ± 21.3 | 956 ± 126 | 4880 ± 407 | 657 ± 67.8 |
EtOH | 3870 ± 272 | 2600 ± 275 | 303 ± 14.3*** | 829 ± 88.3 | 5063 ± 498 | 984 ± 104*** |
GluN2B | ||||||
Control | 3540 ± 436 | 2120 ± 310 | 56 ± 3.1 | 1040 ± 98.5 | 3020 ± 361 | 379 ± 14.2 |
EtOH | 3200 ± 495 | 2830 ± 870 | 39 ± 3.01*** | 993 ± 172 | 2540 ± 512 | 497 ± 40.6* |
Rate constants obtained from fitting open and shut events within bursts to a kinetic model (Fig. 5C). Values (in s−1) are the means ± S.E. from N = 7 patches. Asterisks denote significant differences from control (paired t-tests; *** P < 0.001, * P < 0.05)