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. Author manuscript; available in PMC: 2023 Jun 15.
Published in final edited form as: Clin Cancer Res. 2022 Dec 15;28(24):5405–5418. doi: 10.1158/1078-0432.CCR-22-0963

Fig. 3. Orthogonal analyses of siHIF2 and PT2399 in TGs define the HIF2 transcriptome in ccRCC.

Fig. 3.

A. Venn diagram showing shared downregulated genes (FDR < 0.05 and LogFC < −1) by A1HIF2 and PT2399 in TGs (11 vehicle- and 11 A1HIF2-treated tumors from XP165, XP283, XP289, and XP374; and 12 vehicle- and 12 PT2399-treated tumors from XP144, XP164, XP373, XP374, and XP453). B. Heatmap of the overlapping 147 significantly downregulated genes. C. Unsupervised GSEA of overlapping 147 genes showing convergence on MYC, E2F, and G2M targets.