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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Mol Psychiatry. 2022 Sep 2;27(12):4829–4842. doi: 10.1038/s41380-022-01744-y

Figure 6. Summary of mechanisms affecting milk quality and offspring brain and behavior following maternal immune activation (MIA) during the mid-lactational period.

Figure 6.

Mid-lactational MIA experienced on postnatal day (P)10 is associated with changes in the milk transcriptome on both P10 and P11, in addition to increased milk corticosterone concentrations and microbial expression of Christensenellaceae on P10. In concert, these effects may lead to reduced LPS binding protein in milk on P10 and fat content on P11. We propose that this altered milk profile is one mechanism by which mid-lactational MIA contributes to the emergence of sex-specific behavioral and physiological changes across the early life of offspring. LPS – lipopolysaccharide; MR- mineralocorticoid receptor.