Table 2.

The significant 13 DMPs ranked by p-value associated with optimism in site-by-site meta-analyses based on the homogeneous probes in both race/ethnicity and gender in WHI and NAS.

CpG	Annotated gene a	Other close gene a	Chr	Position a	p-value	Difference in DNAm b	SE c	Heterogeneity I2 (%), p-value d
cg23032421	IL5RA	-	3	3152038	2.68×10−06	2.12×10−04	4.52×10−05	0.00, 0.68
cg24856537	NOTCH4	-	6	32169929	3.72×10−06	1.41×10−04	3.05×10−05	19.52, 0.28
cg18583565	-	MGMT	10	131567980	8.55×10−06	−1.70×10−04	3.79×10−05	0.00, 0.78
cg00702840	-	MDH2	7	75703958	1.15×10−05	−1.20×10−04	2.62×10−05	0.00, 0.78
cg04219552	-	DYSF	2	72126504	1.52×10−05	9.17×10−05	2.12×10−05	0.00, 0.66
cg05372549	SRM	-	1	11119861	2.45×10−05	2.29×10−05	5.42×10−06	0.00, 0.87
cg15560586	CSNK1G1	-	15	64648483	2.73×10−05	−3.10×10−05	7.39×10−06	0.00, 0.54
cg03451670	AGAP1	-	2	236579469	3.14×10−05	−2.50×10−04	5.91×10−05	0.00, 0.48
cg05065507	TACSTD2	-	1	59042931	3.24×10−05	−3.10×10−04	7.44×10−05	0.00, 0.76
cg06418871	MARVELD2	-	5	68710831	3.26×10−05	−2.60×10−04	6.28×10−05	0.00, 0.70
cg24329557	GCM2	-	6	10882326	3.45×10−05	2.53×10−04	6.11×10−05	0.00, 0.43
cg27288968	PAXBP1	-	21	34106765	3.76×10−05	1.37×10−04	3.32×10−05	0.00, 0.91
cg16303846	DOCK10	-	2	225907539	5.10×10−05	−5.70×10−05	1.41×10−05	0.00, 0.95

Note: The models adjusted for age, race/ethnicity (WHI_AS315 and WHI_BAA23 only), education, smoking status, pack-years, body mass index, case status (WHI_BAA23 only), and methylation-related technical covariates.

Abbreviations: DMPs, differentially methylated probes; CpG, cytosine-phosphate-guanine; DNAm, DNA methylation; Chr, chromosome; SE, standard error; I², I-squared.

^aThe University of California Santa Cruz UCSC database (GRCh37/hg19)

^bDifference in DNAm level (% 5mC) per 1% increase of maximum possible in optimism

^cStandard error in DNAm level (% 5mC) per 1% increase of maximum possible in optimism

^dI² < 50% and p-value of heterogeneity > 0.05 were considered as homogenous across sub-studies