Table 3.
Univariate and multivariate Cox proportional hazard regression analysis for disability.
| Baseline Variables | EDSS≥6 | EDSS≥8 | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| Onset age | 1.59 (1.31 - 1.94) | <0.001 | 1.47 (1.20- 1.88) | <0.001 | 2.05 (1.46 - 2.89) | <0.001 | 1.74 (1.25 - 2.47) | 0.002 |
| Female | 1.02 (0.52 - 1.99) | 0.964 | / | / | 0.73 (0.28 - 1.94) | 0.526 | / | / |
| TM as first attack | 1.58 (0.97 - 2.57) | 0.068 | 1.04 (0.54 - 1.93) | 0.906 | 1.39 (0.64 - 3.02) | 0.403 | / | / |
| ON as first attack | 0.45 (0.24 - 0.82) | 0.009 | 0.50 (0.19 - 0.94) | 0.035 | 0.35 (0.12- 1.02) | 0.055 | 0.38 (0.12 - 1.18) | 0.093 |
| Brainstem/Cerebral as first attack | 1.14 (0.54 - 2.40) | 0.725 | / | / | 0.55 (0.23 - 1.31) | 0.179 | / | / |
| Abnormal CSF | 2.24 (1.35 - 3.70) | 0.002 | 2.26 (1.34 - 3.83) | 0.002 | 3.20 (1.43 - 7.18) | 0.005 | 2.95 (1.29 - 6.74) | 0.010 |
| AQP4-IgG positive | 1.03 (0.53 - 2.04) | 0.923 | / | / | 1.32 (0.49 - 3.54) | 0.581 | / | / |
| PE/IVIG during acute phase | 1.58 (0.98 - 2.56) | 0.063 | 1.43 (0.86 - 2.40) | 0.172 | 0.68 (0.32 - 1.47) | 0.330 | / | / |
| Maintenance treatment of IST | 0.52 (0.28 - 0.93) | 0.028 | 0.72 (0.37 - 1.36) | 0.302 | 0.26 (0.11 - 0.61) | 0.002 | 0.43 (0.17 - 1.05) | 0.063 |
EDSS, Expanded Disability Status Scale; HR, hazard ratio; CI, confidence interval; TM, transverse myelitis; ON, optic neuritis; CSF, cerebrospinal fluid; AQP4-IgG, aquaporin-4 immunoglobin G; PE, plasma exchange; IVIG, intravenous immunogloblin; IST, immunosuppressive therapy.
p values <0.05 were bolded.