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. 2022 Dec 8;10:982894. doi: 10.3389/fbioe.2022.982894

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Copyright © 2022 Song, Wang, Guo, Li, Huang, Yang, Tang, Fu, Yang, Chen, Chen and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of osteochondral repair in the untreated group (NC), scaffold-only group (Ept–) and Ept loaded scaffold group (Ept+) at 4 and 8 weeks. (A) Macroscopic analysis, hematoxylin and eosin staining, and safranin O staining of the knee joints. Black rectangle indicates the osteochondral defects. (B) Macroscopic analysis for cartilage repair with the modified International Cartilage Repair Society (ICRS) gross grading (n = 3). (C) ICRS visual scoring based on panel D (n = 3). (D) The immunohistochemical staining against collagen (Col) types I, II and X of the regenerated tissue at 4 and 8 weeks. Mean ± SD.