Table 4.
Factors in correlation with 6-month poor prognosis following aneurysmal subarachnoid hemorrhage.
| Poor prognosis | Good prognosis | P-value | |
|---|---|---|---|
| Male | 42 (42.9%) | 71 (44.7%) | 0.778 |
| Age (years) | 52.0 ± 11.1 | 50.6 ± 10.2 | 0.334 |
| Cigarette smoking | 32 (32.7%) | 51 (32.1%) | 0.923 |
| Alcohol drinking | 29 (29.6%) | 37 (23.3%) | 0.260 |
| Hypertension | 24 (24.5%) | 29 (18.2%) | 0.229 |
| Diabetes mellitus | 15 (15.3%) | 8 (5.0%) | 0.005 |
| Hyperlipidemia | 18 (18.4%) | 20 (12.6%) | 0.204 |
| Previous use of statins | 7 (7.1%) | 14 (8.8%) | 0.637 |
| Previous use of anticoagulation drugs | 9 (9.2%) | 4 (2.5%) | 0.018 |
| Previous use of antiplatelet drugs | 6 (6.1%) | 6 (3.8%) | 0.386 |
| Hunt-Hess scores | 4 (3–4) | 2 (2–3) | < 0.001 |
| Modified Fisher scores | 3 (2–3) | 2 (1–2) | < 0.001 |
| Aneurysms located at anterior circulation | 80 (81.6%) | 127 (79.9%) | 0.729 |
| Cystic aneurysms | 83 (84.7%) | 132 (83.0%) | 0.724 |
| Aneurysms with diameter of < 10 mm | 53 (54.1%) | 100 (62.9%) | 0.162 |
| Surgical clipping for securing aneurysms | 33 (33.7%) | 63 (39.6%) | 0.338 |
| Acute hydrocephalus | 23 (23.5%) | 9 (5.7%) | < 0.001 |
| Intraventricular hemorrhage | 15 (15.3%) | 11 (6.9%) | 0.030 |
| External ventricular drain | 17 (17.3%) | 16 (10.1%) | 0.090 |
| Admission time after stroke (h) | 10.1 (4.6–14.2) | 10.3 (5.1–14.7) | 0.729 |
| Blood-collection time after stroke (h) | 11.8 (6.7–16.0) | 11.6 (6.5–16.6) | 0.975 |
| Blood glucose levels (mmol/L) | 12.7 (8.8–17.3) | 10.3 (8.6–12.0) | < 0.001 |
| Blood leukocyte count ( × 109/L) | 7.8 (6.5–10.4) | 7.5 (5.9–11.3) | 0.963 |
| Serum HIF-1α levels > 384.0 pg/ml | 70 (71.4%) | 30 (18.9%) | < 0.001 |
Variables were reported as count (proportion), mean ± standard deviation, or median (percentiles 25th−75th) where appropriate. Statistical methods included the student t-test, Mann–Whitney test, Fisher's exact test, and χ2 test. HIF-1α means hypoxia-inducible factor 1alpha. Poor outcome was defined as extended Glasgow outcome scale scores of 1–4.