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. 2022 Dec 8;13:1060441. doi: 10.3389/fimmu.2022.1060441

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Copyright © 2022 Zhou, Chen, Zhong, Xia, Zhao, Zhao, Xu, Guo and You

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depicting a proposed model for LXA4. LXA4 alleviates MSU-crystal-induced NLRP3 inflammasome activation by suppressing Nrf2 to promote TXNRD2.