Table 4.
Mixed-effects multivariable logistic regression model of risk factors for CRE BSI
Baseline characteristic | aOR | 95% CI | P |
---|---|---|---|
Prior exposure to a third-generation cephalosporina | 2.21 | 1.17-4.17 | 0.015 |
Prior exposure to a carbapenema | 2.80 | 1.54-5.10 | 0.001 |
Prior CRE colonization/infectionb | 9.86 | 4.88-19.93 | <0.001 |
Time from transplantation to EB BSI (per d) | 0.99 | 0.99-1.00 | 0.051 |
Chronic immunosuppression with mycophenolatec | 0.47 | 0.25-0.89 | 0.021 |
Organ transplant type | |||
Kidney | Ref | ||
Liver | 2.64 | 1.23-5.65 | 0.012 |
Heart | 2.69 | 0.80-9.02 | 0.108 |
Lung | 3.76 | 1.40-10.09 | 0.009 |
Pancreas | 0.68 | 0.08-6.57 | 0.740 |
Exposure within the 6 mo before the EB BSI.
CRE organism isolated on any microbiological culture from any anatomical site in the 12 months before the EB BSI. No surveillance cultures were performed at the included study sites.
Immunosuppression assessed at the time of the EB BSI.
aOR, adjusted odds ratio; BSI, bloodstream infection; CI, confidence interval; CRE, carbapenem-resistant Enterobacterales; EB, Enterobacterales; ref, reference.