Table 2.

Indications for treatment and prophylaxis

Indications for treatment	Indications for prophylaxis (Prevention of HBV transmission/re-activation)
Decompensated cirrhosis	Post-liver transplantation
Compensated cirrhosis regardless of HBV DNA and ALT levels	Post-liver transplantation from anti-HBc positive donor to HBsAg negative recipient
HBV presenting with acute liver failure	HBsAg positive mother during the third trimester with HBV DNA >200,000 IU/mL
HBeAg positive immune active (HBV DNA >20,000 IU/mL and ALT >2XULN)	HBsAg positive patients receiving immunosuppression/chemotherapy
HBeAg negative immune active (HBV DNA >2,000 IU/mL and ALT >2XULN)	HBsAg negative, anti-HBc positive patients receiving immunosuppression / chemotherapy and at high risk for reactivation
HBV/HDV Co-infection with HBV DNA >2,000 IU/mL
HBV / HIV Co-infection
HBV presenting with extrahepatic manifestations
HBsAg positive healthcare worker with HBV DNA>2,000 IU/mL