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. Author manuscript; available in PMC: 2023 Dec 12.
Published in final edited form as: Cancer Cell. 2022 Nov 17;40(12):1521–1536.e7. doi: 10.1016/j.ccell.2022.10.021

Figure 2. Identification, training, and validation of 812 gene classifier.

Figure 2.

A) Heatmap of 812 differentially expressed (DE) genes from cases vs controls analysis (5-year outcome) in TBCRC. Covariates show ER and HER2 status, DCIS grade, treatment, and type of iBE/no iBE. B) ROC curve of the 812 gene classifier in RAHBT. C) Kaplan-Meier plot of time to iBE (5-year outcome) stratified by classifier risk groups in RAHBT. D-E) Kaplan-Meier plot of time to invasive progression (full follow-up) stratified by classifier risk groups in TBCRC (D) and RAHBT (E). C-E) P-values from log-rank tests. F-G) Forest plot of multivariable Cox regression analysis including classifier risk groups, treatment, age, DCIS grade, and ER status for invasive iBEs (full follow-up) in TBCRC (F) and RAHBT (G). See also Figure S1 and Table S3.