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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Glia. 2022 Oct 27;71(2):450–466. doi: 10.1002/glia.24286

Figure 2. GFAP promoter-driven YY1 deletion caused phenotypic abnormalities and impairment of locomotor activity, motor coordination, and recognition memory.

Figure 2.

(A) Image showing differences in size between WT and YY1 cKO mice. (B) The body weight of mice in each group was measured prior to the experiments. (C-H) Locomotor activity, motor coordination, and recognition memory were analyzed. (C) The traces show a representative mouse movement. (D) Total distance traveled, ambulatory (walking) activity count, movement speed, (E) vertical activity, and (F) latency to fall were recorded and compared between groups. Total exploration of the novel object (G) and ability to discriminate between NO and FO were quantified and compared between groups. ##, p<0.01 ###, p<0.001 ####, p<0.0001 compared with the control (WT) (Student t-test; n = 6-7). Data are expressed as mean ± SD.