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. 2022 Dec 21;12:22037. doi: 10.1038/s41598-022-26510-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A case in which the pathology diagnosis by transbronchial lung cryobiopsy (TBLC) was inconsistent with the diagnosis of MDD. (A), (B): pathology by TBLC. Dense fibrosis with architectural destruction were observed (blue curcle). However, normal alveolar structure beside the dense fibrosis was not observed in this specimen. (C), (D): high-resolution computed tomography (HRCT). Centrilobular nodules were observed in the upper lobes of the lung (orange arrow). In addition, reticular shadows or honeycombing which suggests UIP pattern were not observed.