Table 2.

Diagnostic accuracy of a ML-assisted system for active TAO and each inflammatory sign of CAS in the test set constructed from entire dataset.

	Sensitivity (95% CI), %	Specificity (95% CI), %	AUC (95% CI), %
Active TAO (CAS ≥ 3)	72.7 (70.6, 74.8)	83.2 (81.7, 84.8)
Redness of eyelids	63.7 (61.7, 65.7)	75.3 (73.9, 76.6)	77.1 (76.0, 78.3)
Redness of conjunctiva	71.8 (70.4, 73.1)	73.4 (71.6, 75.3)	80.9 (80.0, 81.8)
Swelling of eyelids	84.8 (83.8, 85.8)	50.6 (47.2, 53.9)	77.1 (75.6, 78.6)
Inflammation of the caruncle and/or plica	42.6 (38.6, 46.5)	90.6 (89.6, 91.5)	75.0 (73.2, 76.8)
Conjunctival edema	52.9 (49.1, 56.7)	88.0 (87.0, 89.0)	79.1 (77.2, 81.0)

ML machine learning, CI confidence interval, AUC area under the curve, TAO thyroid associated orbitopathy, CAS clinical activity score.