Table 4.
Familial relative risk for FMD and AAA, as well as absolute risk for DAAD (which includes FMD, AAA, non-abdominal aortic aneurysm, and arterial dissection). Relative risk (RR) and 95% confidence intervals (CI) were computed based upon the distribution of the individuals in each category with the listed findings (n) as compared to the total number of individuals per category (N). Population prevalence (P) of 3.34% for FMD16 and 4.9% for AAA17-20 was used to calculate relative risk. The absolute risk is represented by the probability that a relative is affected (p=n/N).
| Family members with FMD | Family members with AAA |
Family Member
with diagnosed DAAD+AAA |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | N | p=n/N | RR [95% CI] | n | N | p=n/N | RR [95% CI] | n | N | p=n/N | |
| Female Parents | 2 | 72 | 2.80% | 0.83 [.20 – 3.40] | 0 | 72 | - | 6 | 72 | 8.30% | |
| Male Parents | 0 | 72 | - | 8 | 72 | 11.10% | 2.27 [1.12-4.60] | 13 | 72 | 18.10% | |
| Female Siblings | 4 | 91 | 4.40% | 1.32 [.48 – 3.63 | 0 | 91 | - | 9 | 91 | 9.90% | |
| Male Siblings | 0 | 94 | - | 0 | 94 | - | 6 | 94 | 6.40% | ||
| Female Offspring | 5 | 64 | 7.80% | 2.34 [.95-5.78] | 0 | 64 | - | 8 | 64 | 12.50% | |
| Male Offspring | 0 | 70 | - | 0 | 70 | - | 1 | 70 | 1.40% | ||
| All Relatives | 11 | 463 | 2.40% | 0.71 [.36-1.39] | 8 | 463 | 1.70% | 0.35 [.17-.74] | 43 | 463 | 9.30% |
| Male Relatives | 0 | 236 | - | 8 | 236 | 3.40% | 0.69 [.33-1.44] | 20 | 236 | 8.50% | |
| Female Relatives | 11 | 227 | 4.80% | 1.45 [.75-2.82] | 0 | 227 | - | 23 | 227 | 10.10% | |
| Male Siblings + Male Offspring | 0 | 164 | - | 0 | 164 | - | 7 | 164 | 4.30% | ||
| Female Siblings + Female Offspring | 9 | 155 | 5.80% | 1.74 [.85-3.56] | 0 | 155 | - | 17 | 155 | 11.00% | |