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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Circ Genom Precis Med. 2022 Nov 14;15(6):e003496. doi: 10.1161/CIRCGEN.121.003496

Table 4.

Familial relative risk for FMD and AAA, as well as absolute risk for DAAD (which includes FMD, AAA, non-abdominal aortic aneurysm, and arterial dissection). Relative risk (RR) and 95% confidence intervals (CI) were computed based upon the distribution of the individuals in each category with the listed findings (n) as compared to the total number of individuals per category (N). Population prevalence (P) of 3.34% for FMD16 and 4.9% for AAA17-20 was used to calculate relative risk. The absolute risk is represented by the probability that a relative is affected (p=n/N).

Family members with FMD Family members with AAA Family Member
with diagnosed
DAAD+AAA
n N p=n/N RR [95% CI] n N p=n/N RR [95% CI] n N p=n/N
Female Parents 2 72 2.80% 0.83 [.20 – 3.40] 0 72 - 6 72 8.30%
Male Parents 0 72 - 8 72 11.10% 2.27 [1.12-4.60] 13 72 18.10%
Female Siblings 4 91 4.40% 1.32 [.48 – 3.63 0 91 - 9 91 9.90%
Male Siblings 0 94 - 0 94 - 6 94 6.40%
Female Offspring 5 64 7.80% 2.34 [.95-5.78] 0 64 - 8 64 12.50%
Male Offspring 0 70 - 0 70 - 1 70 1.40%
All Relatives 11 463 2.40% 0.71 [.36-1.39] 8 463 1.70% 0.35 [.17-.74] 43 463 9.30%
Male Relatives 0 236 - 8 236 3.40% 0.69 [.33-1.44] 20 236 8.50%
Female Relatives 11 227 4.80% 1.45 [.75-2.82] 0 227 - 23 227 10.10%
Male Siblings + Male Offspring 0 164 - 0 164 - 7 164 4.30%
Female Siblings + Female Offspring 9 155 5.80% 1.74 [.85-3.56] 0 155 - 17 155 11.00%