Table 7.
FDA approved covalent drugs in CovBinderInPDB.
| CovBinder ID | DrugBank ID | drug name | therapeutic area | FDA approval date | |||||
|---|---|---|---|---|---|---|---|---|---|
| CB0000223 | DB01053 | penicillin G potassium | anti-infective | 1947-02-06 | |||||
| CB0002172 | DB00945 | aspirin | anti-inflammatory | 1950-04-12 | |||||
| CB0000767 | DB00822 | disulfiram | chronic alcoholism | 1951-08-28 | |||||
| CB0000107 | DB00677 | isoflurophate | chronic glaucoma | 1957-04-02 | |||||
| CB0001276 | DB00417 | penicillin V potassium | anti-infective | 1958-01-13 | |||||
| CB0000388 | DB01057 | echothiophate | chronic glaucoma | 1960-06-27 | |||||
| CB0001608 | DB00607 | nafcillin | anti-infective | 1965-10-11 | |||||
| CB0001263 | DB03754 | tromethamine | blood acid reducer | 1965-12-16 | |||||
| CB0000469 | DB00415 | ampicillin | anti-infective | 1965-12-17 | |||||
| CB0000941 | DB00319 | piperacillin | anti-infective | 1967-07-24 | |||||
| CB0001893 | DB00567 | cephalexin | anti-infective | 1971-01-04 | |||||
| CB0000595 | DB01147 | cloxacillin | anti-infective | 1971-04-01 | |||||
| CB0000725 | DB00713 | oxacillin | anti-infective | 1971-04-08 | |||||
| CB0000272 | DB00766 | amoxicillin | anti-infective | 1974-01-18 | |||||
| CB0001978 | DB01607 | ticarcillin | anti-infective | 1976-11-09 | |||||
| CB0001556 | DB01326 | cefamandole | anti-infective | 1978-09-27 | |||||
| CB0000270 | DB01331 | cefoxitin | anti-infective | 1978-10-18 | |||||
| CB0000123 | DB00493 | cefotaxime | anti-infective | 1981-03-11 | |||||
| CB0000221 | DB00727 | nitroglycerin | angina | 1981-05-28 | |||||
| CB0000574 | DB01212 | ceftriaxone | anti-infective | 1984-12-21 | |||||
| CB0000116 | DB01598 | imipenem | anti-infective | 1985-11-26 | |||||
| CB0000064 | DB09324 | sulbactam | anti-infective | 1986-12-31 | |||||
| CB0000427 | DB00355 | aztreonam | anti-infective | 1986-12-31 | |||||
| CB0000872 | DB00671 | cefixime | anti-infective | 1989-04-28 | |||||
| CB0000944 | DB00447 | loracarbef | anti-infective | 1991-12-31 | |||||
| CB0000230 | DB01606 | tazobactam | anti-infective | 1993-10-22 | |||||
| CB0002030 | DB00847 | cysteamine | cystinosis | 1994-08-15 | |||||
| CB0000115 | DB00760 | meropenem | anti-infective | 1996-06-21 | |||||
| CB0000801 | DB00828 | fosfomycin | anti-infective | 1996-12-19 | |||||
| CB0001216 | DB01083 | orlistat | gastro-intestinal | 1999-04-23 | |||||
| CB0000569 | DB00451 | levothyroxine | hypothyroidism | 2000-08-21 | |||||
| CB0000334 | DB00188 | bortezomib | cancer | 2003-05-13 | |||||
| CB0000120 | DB06211 | doripenem | anti-infective | 2007-10-12 | |||||
| CB0000002 | DB05521 | telaprevir | anti-HCV | 2011-05-23 | |||||
| CB0000265 | DB08889 | carfilzomib | cancer | 2012-07-20 | |||||
| CB0001239 | DB08916 | afatinib | cancer | 2013-07-12 | |||||
| CB0000083 | DB09053 | ibrutinib | cancer | 2013-11-13 | |||||
| CB0000277 | DB09060 | avibactam | anti-infective | 2015-02-25 | |||||
| CB0000730 | DB09330 | osimertinib | cancer | 2015-11-13 | |||||
| CB0001562 | DB09570 | ixazomib | cancer | 2015-11-20 | |||||
| CB0001879 | DB11828 | neratinib | cancer | 2017-07-17 | |||||
| CB0000788 | DB12107 | vaborbactam | anti-infective | 2017-08-29 | |||||
| CB0000587 | DB11963 | dacomitinib | cancer | 2018-09-27 | |||||
| CB0000473 | DB11942 | selinexor | cancer | 2019-07-03 | |||||
| CB0000871 | DB12377 | relebactam | anti-infective | 2019-07-16 | |||||
| CB0001860 | DB15035 | zanubrutinib | cancer | 2019-11-14 | |||||
| CB0000212 | DB14219 | monomethyl fumarate | multiple sclerosis | 2020-04-28 |