Figure 1:

Associations between hemoglobin A1C (HbA1c) and estimated glomerular filtration rate (eGFR) decline stratified by selected sleep metrics, evaluating if these sleep characteristics (stage N3 sleep, napping frequency, and sleep timing) modify the relationship between HbA1c and changes in kidney function, by high-dimensional regression analyses. The dot with bar represents the association estimate with 95% confidence interval. For example, a one unit increase in baseline HbA1c was associated with: 0.04 (p=0.204) and 0.25 (p<.001) (ml/min/1.73m²/year) estimated glomerular filtration rate decline for the participants with polysomnography (PSG) stage N3 sleep above or equal to the median value and the participants below median