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. 2022 Dec 22;5:1401. doi: 10.1038/s42003-022-04357-x

Fig. 2. Increased gut microbial diversity is associated with better outcomes in murine model of fibrosis.

Fig. 2

a Shannon diversity index scores for mice housed in ABSL-1 and ABSL-2 facilities and intranasally inoculated with 75 μl containing 0.04 Units of bleomycin or saline (saline) (n = 13-27 mice per cohort). The boxes show the median, as well as the 25th and 75th quartiles. The whiskers extend to 1.5*IQR. Each dox represents one mouse. b Phyla-level composition of the gut microbiome of ABSL-1 and ABSL-2 mice. c Nonlinear multidimensional scaling (MDS) plot showing differences in microbial taxonomic composition based on Jaccard dissimilarities. d Results of linear discriminant analysis showing taxa that are overrepresented in ABSL-1 or ABSL-2 mice. e Within-sample diversity for lung microbiome samples from mice housed on ABSL1 and ABSL2 floors. f Nonmetric multidimensional scaling plot based on Bray-Curtis dissimilarities showing the lung microbiome communities of mice housed on ABSL1 and ABSL2 floors. The experiment was independently conducted once.