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. 2022 Dec 21;13(12):1063. doi: 10.1038/s41419-022-05457-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — After transfection with different plasmids (SK, WT, G82R, L85P, G82R/L85P, and P289R) in HeLa cells, the morphology of ER was observed using TEM (A–F). The epileptic variants induced ER swelling (as indicated by the red arrows in (C–F). Scale bar, 1 μm. Magnified images are shown in the column of (a–f). Scale bar, 200 nm.