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. 2022 Dec 21;11:43. doi: 10.1186/s13619-022-00153-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cell subclusters in vascular endothelial and mural cells. A UMAP plot to visualize three endothelial subclusters (EC1, EC2, and EC3). B UMAP plots to show the highly expressed marker genes of three endothelial subclusters. C Heatmap plot to show the average expression levels of the DEGs in the three endothelial subclusters. The descriptions right to the heatmap are the top KEGG enriched pathways (adjust p value < 0.05). D UMAP plot to visualize the four mural subclusters (MC1, MC2, MC3, and MC4). E UMAP plots to show the highly expressed marker genes of four mural subclusters. F Heatmap plot to show the average expression levels of the DEGs in the four mural subclusters. The descriptions right to the heatmap are the top KEGG enriched pathways (adjust p value < 0.05)