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. 2022 Dec 21;5:1400. doi: 10.1038/s42003-022-04338-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Definition of REE. b Count of REEs from normal samples per stage. c Percentage of 3'-UTR REEs in early stages of embryogenesis. See also Supplementary Fig. 13 for percentages of general edits. d Percentage of exonic edits and REEs (shown in red) in the early stages of embryogenesis. e Sankey plot describing the numbers of REEs passed to subsequent early stages. For clarity, only REEs observed in at least one of the two stages appear in each subplot. For c–e, we considered only REEs on protein-coding genes. See also Supplementary Figs. 14 and 15 for the percentage of 3'-UTR REEs, and the percentage of exonic edits and REEs in the late stages of embryogenesis.