FIGURE 5.

Gasdermin-D activation is required for surface expression of TCR-γδ ligand. LPS- or B. burgdorferi (Bb)–activated monocytes were treated with either FLTD (100 μM), necrosulfonamide (NS) (10 μM), dimethyl fumarate (DMF) (25 μM), or fumarate hydratase inhibitor FHIN1 (25 μM). After 48 h cells were stained with sTCR-γδ tetramer. (A) Representative histograms with number inserts indicating mean fluorescence intensity of entire histogram. (B) Graphs summarize findings from all experiments. **p < 0.005, ***p < 0.0005.