TABLE 2.

Ultrasound cardiogram parameters at baseline and 24-week follow-up.

UCG parameters	ARB
	Baseline	24-week	Differences between baseline and 24-week	Change ratio
LAD (mm)	43.40 ± 6.05	41.74 ± 5.20	P = 0.105	−2.80 ± 11.29%
RAD (mm)	37.80 ± 6.18	34.91 ± 3.88	P = 0.012	−5.26 ± 12.45%
LVEDD (mm)	46.03 ± 5.37	47.11 ± 4.61	P = 0.164	+3.51 ± 11.40%
RVEDD (mm)	35.43 ± 4.08	32.03 ± 4.95	P = 0.001	−8.78 ± 14.39%
LVEF (%)	64.28 ± 1.34	65.21 ± 6.73	P = 0.647	+2.28 ± 13.78%
	ARNI
	Baseline	24-week	Differences between baseline and 24-week	Change ratio
LAD (mm)	44.00 ± 6.83	40.13 ± 5.64	P < 0.001	−8.05 ± 10.16%
RAD (mm)	39.43 ± 6.93	34.83 ± 4.48	P < 0.001	−10.38 ± 11.67%
LVEDD (mm)	50.09 ± 6.91	48.70 ± 6.16	P = 0.064	−2.30 ± 8.43%
RVEDD (mm)	34.71 ± 5.29	31.71 ± 4.34	P = 0.010	−7.09 ± 16.15%
LVEF (%)	56.05 ± 13.37	59.87 ± 8.31	P = 0.021	+11.49 ± 24.65%
	Differences between ARB and ARNI
	Baseline	24-week	Change ratio
LAD (mm)	P = 0.699	P = 0.223	P = 0.046
RAD (mm)	P = 0.303	P = 0.889	P = 0.083
LVEDD (mm)	P = 0.008	P = 0.232	P = 0.019
RVEDD (mm)	P = 0.529	P = 0.779	P = 0.648
LVEF (%)	P = 0.003	P = 0.005	P = 0.061

ARNI group had a significant larger LVEDD and lower LVEF at the baseline compared to ARB group. At the 24-week, the LVEF was still lower in ARNI group.

LAD and LVEDD change ratios were higher in ARNI group. LAD, left atrium diameter; RAD, right atrium diameter; LVEDD, left ventricle end-diastolic diameter; RVEDD, right ventricle end-diastolic diameter; LVEF, left ventricle ejection fraction.

Change ratio = (“24-week” − “baseline”)/“baseline” × 100%.