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. 2022 Dec 8;9:1048077. doi: 10.3389/fcvm.2022.1048077

TABLE 5.

Ultrasound cardiogram parameters in all animal groups.

UCG parameter Control

Baseline 8-week follow-up Differences between baseline and 8-week follow-up
LAD (mm) 19.87 ± 0.80 24.39 ± 4.11 P = 0.096
RAD (mm) 19.68 ± 0.92 23.96 ± 1.16 P = 0.048
LAVI (ml/m2) 17.34 ± 0.89 22.76 ± 5.80 P = 0.206
LAEF (%) 56.51 ± 3.11 34.63 ± 7.96 P = 0.016
LVEDVI (ml/m2) 46.36 ± 2.73 54.29 ± 3.27 P = 0.115
LVEF (%) 63.36 ± 4.38 55.47 ± 4.39 P < 0.001
E/A 1.19 ± 0.05 1.89 ± 0.10 P = 0.018
E/E′ 8.27 ± 0.75 12.55 ± 0.78 P < 0.001

ARB

Baseline 8-week follow-up Differences between baseline and 8-week follow-up

LAD (mm) 19.98 ± 0.91 18.39 ± 2.18 P = 0.180
RAD (mm) 18.77 ± 0.97 19.72 ± 2.88 P = 0.392
LAVI (ml/m2) 14.20 ± 1.14 18.55 ± 2.87 P = 0.065
LAEF (%) 56.06 ± 3.90 47.79 ± 5.69 P = 0.055
LVEDVI (ml/m2) 46.30 ± 2.04 52.96 ± 15.72 P = 0.403
LVEF (%) 64.57 ± 3.58 54.06 ± 6.60 P < 0.001
E/A 1.13 ± 0.11 1.59 ± 0.20 P = 0.430
E/E′ 6.64 ± 1.17 9.31 ± 2.79 P = 0.012

ARNI

Baseline 8-week follow-up Differences between baseline and 8-week follow-up

LAD (mm) 21.33 ± 2.25 20.57 ± 5.18 P = 0.523
RAD (mm) 19.12 ± 1.10 17.28 ± 4.29 P = 0.332
LAVI (ml/m2) 14.71 ± 1.66 18.59 ± 3.85 P = 0.016
LAEF (%) 57.05 ± 2.50 52.09 ± 2.97 P = 0.030
LVEDVI (ml/m2) 43.73 ± 2.61 44.62 ± 6.30 P = 0.837
LVEF (%) 64.26 ± 4.26 65.09 ± 2.56 P < 0.001
E/A 1.12 ± 0.11 1.34 ± 0.13 P = 0.419
E/E′ 9.73 ± 1.66 7.63 ± 2.08 P = 0.008

Differences at baseline between all groups Differences at 8-week follow-up

Control vs. ARB Control vs. ARNI ARB vs. ARNI

LAD (mm) P = 0.745 P = 0.042 P = 0.291 P = 0.468
RAD (mm) P = 0.810 P = 0.034 P = 0.024 P = 0.380
LAVI (ml/m2) P = 0.227 P = 0.240 P = 0.275 P = 0.987
LAEF (%) P = 0.977 P = 0.036 P = 0.006 P = 0.228
LVEDVI (ml/m2) P = 0.703 P = 0.874 P = 0.034 P = 0.362
LVEF (%) P = 0.977 P = 0.735 P = 0.009 P = 0.021
E/A P = 0.849 P = 0.036 P = 0.001 P = 0.076
E/E′ P = 0.267 P = 0.066 P = 0.004 P = 0.369

There was no statistical difference at baseline between all groups. At 8-week follow-up, only LVEF was significantly larger in ARNI group compared to ARB group.

UCG, ultrasound cardiogram; LAD, left atrium diameter; RAD, right atrium diameter; LAVI, left atrium volume index; LAEF, left atrium ejection fraction; LVEDVI, left ventricle end-diastolic volume index; LVEF, left ventricle ejection fraction.