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. 2022 Dec 8;13:1067338. doi: 10.3389/fimmu.2022.1067338

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Copyright © 2022 Jiang, Zhang, Jiang, Sun, Li, Zhang, Shen and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profiling of SPP1⁺ macrophage function. (A) The UMAP plot displays 18 myeloid cell subclusters; (B) The expression levels of specific markers for each myeloid cell type are plotted onto a UMAP map; (C) The expression levels of specific markers for each macrophage subtype were plotted onto the UMAP map; (D) The histogram indicates the proportions of myeloid cell populations in each infection period; (E) The box plots show the classification of macrophage clusters into M1 and M2. (F) The volcano plot of DEGs between the SPP1⁺ and C1QC⁺ macrophages. Upregulated and downregulated genes are highlighted in blue and red, respectively; (G) The bar plot depicting the GSVA results of SPP1⁺ and C1QC⁺ macrophage differential genes.