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. 2022 Dec 14;22:19–29. doi: 10.1016/j.reth.2022.11.005

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — The effects of exosomes derived from CSCs with CDKN2B-AS1 silencing on the migration and invasion of thyroid cancer cells.(A–B) RT-qPCR detection found that sh-CDKN2B-AS1 reduced the level of CDKN2B-AS1 in exosomes.(C–D) RT-qPCR was performed to examine the effects of exosomes derived from CSCs with CDKN2B-AS1 silencing on the level of CDKN2B-AS1 in thyroid cancer cells.(E–F) Exosomes from CSCs transfected with sh-CDKN2B-AS1 reduced the migration of parental cells, which was tested by wound healing experiments.(G–H) Transwell assay tested the effects of exosomes derived from CSCs with CDKN2B-AS1 silencing on cell invasion in each group. ∗∗p < 0.01, ∗∗∗p < 0.001 vs. sh-NC-EXO (exosomes derived from TPC-1 or SW579 cells-CSCs transfected with sh-NC).