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. 2022 Dec 14;22:19–29. doi: 10.1016/j.reth.2022.11.005

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — CDKN2B-AS1 in exosomes targeted miR-122-5p/P4HA1 axis in recipient thyroid cancer cells.(A) The starBase and GSE113629 data were applied to analyze the miRNAs targeted by CDKN2B-AS1 and acting on thyroid cancer, the results of which showed the targeted binding sites of CDKN2B-AS1 and miR-122-5p.(B) The miRDB (http://mirdb.org/mirdb/index.html) and TargetScan database (http://www.targetscan.org/vert_72/) predicted the target genes of miR-122-5p, and the TargetScan database predicted the targeted binding sites of miR-122-5p and P4HA1.(C–D) The binding relationship between miR-122-5p with CDKN2B-AS1 and P4HA1 was verified by dual-luciferase reporter assay.(E–F) The expressions of miR-122-5p and P4HA1 in thyroid cancer cells were detected by RT-qPCR.(G–J) RT-qPCR was performed to detect the effects of exosomes derived from CSCs with CDKN2B-AS1 silencing on the expressions of miR-122-5p and P4HA1. ∗∗∗p < 0.001 vs. Nthy-ori3-1; ^###p < 0.001 vs. MC (mimic control); ^ˆˆˆp < 0.001 vs. sh-NC-EXO.