Figure 6.

Sex differences in gene expression of HBV-related TCGA-HCCs. (A) The expression levels of AR and ESR1, ESR2. Each dot represents 1 case. (B) The expression of gene sets involved in specified pathways in QD-HCCs and in TCGA-HCCs. The yellow boxes with positive numbers indicate the pathways were up-regulated, the green boxes with negative numbers indicate the pathways were down-regulated in male HCCs compared with female HCCs. AHSP, α-hemoglobin stabilizing protein; AKAP13, a-kinase anchoring protein 13; BMP, bone morphogenetic protein; CDK5, cyclin-dependent kinase-5; CREB, cAMP responsive element binding protein; FCER1, fc ε receptor 1; FGFR4, fibroblast growth factor receptor 4; FPKM, fragments per kilobase of transcript per million fragments mapped; IFNG, interferon γ; logFC, log₂ fold change; MHC, major histocompatibility complex; MYC, myelocytomatosis oncogene; NFκB, nuclear factor-κB; PAR1, protease-activated receptor-1; PCAF, p300/CBP-associating factor; pol III, RNA polymerase III; V2, version 2.