Table 4.
The 71 Identified Genes With Different Mutation Frequencies Between Male and Female QD-HCC Samples
| Genea | Males (N = 47) |
Females (N = 54) |
Pb | ||
|---|---|---|---|---|---|
| n | Frequency | n | Frequency | ||
| FLNCc | 11 | 23.40% | 3 | 5.56% | .021 |
| MEGF6d | 10 | 21.28% | 2 | 3.70% | .009 |
| APOB | 9 | 19.15% | 2 | 3.70% | .030 |
| SSPOd | 9 | 19.15% | 2 | 3.70% | .030 |
| DSTc,d | 9 | 19.15% | 0 | 0.00% | .001 |
| IGSF9B | 8 | 17.02% | 2 | 3.70% | .042 |
| STARD9c | 8 | 17.02% | 2 | 3.70% | .042 |
| CELSR3c | 8 | 17.02% | 1 | 1.85% | .011 |
| TEP1 | 7 | 14.89% | 1 | 1.85% | .024 |
| SPATA31D1d | 7 | 14.89% | 1 | 1.85% | .024 |
| RP1e | 6 | 12.77% | 1 | 1.85% | .048 |
| UNC13A | 6 | 12.77% | 1 | 1.85% | .048 |
| TSHZ1 | 6 | 12.77% | 1 | 1.85% | .048 |
| CEP250 | 6 | 12.77% | 1 | 1.85% | .048 |
| MYO10 | 6 | 12.77% | 1 | 1.85% | .048 |
| GPSM1 | 6 | 12.77% | 1 | 1.85% | .048 |
| IQSEC3 | 6 | 12.77% | 1 | 1.85% | .048 |
| XKR7 | 6 | 12.77% | 1 | 1.85% | .048 |
| ABCA2d,e | 6 | 12.77% | 1 | 1.85% | .048 |
| LRRK1 | 6 | 12.77% | 0 | 0.00% | .008 |
| HCN4d | 6 | 12.77% | 0 | 0.00% | .008 |
| CCDC129d | 5 | 10.64% | 0 | 0.00% | .019 |
| RAVER2 | 5 | 10.64% | 0 | 0.00% | .019 |
| FYCO1 | 5 | 10.64% | 0 | 0.00% | .019 |
| CITc | 5 | 10.64% | 0 | 0.00% | .019 |
| ATP2B1c | 5 | 10.64% | 0 | 0.00% | .019 |
| PHKA2 | 4 | 8.51% | 0 | 0.00% | .044 |
| CCDC136 | 4 | 8.51% | 0 | 0.00% | .044 |
| HK2 | 4 | 8.51% | 0 | 0.00% | .044 |
| RET | 4 | 8.51% | 0 | 0.00% | .044 |
| OR2L2 | 4 | 8.51% | 0 | 0.00% | .044 |
| BCR | 4 | 8.51% | 0 | 0.00% | .044 |
| ZNF429 | 4 | 8.51% | 0 | 0.00% | .044 |
| OPLAH | 4 | 8.51% | 0 | 0.00% | .044 |
| PKD1 | 4 | 8.51% | 0 | 0.00% | .044 |
| FER1L5 | 4 | 8.51% | 0 | 0.00% | .044 |
| PCF11c | 4 | 8.51% | 0 | 0.00% | .044 |
| SLC6A1 | 4 | 8.51% | 0 | 0.00% | .044 |
| SMAD6 | 4 | 8.51% | 0 | 0.00% | .044 |
| ITGA2d | 4 | 8.51% | 0 | 0.00% | .044 |
| DACH1c | 4 | 8.51% | 0 | 0.00% | .044 |
| DDX60Lc | 4 | 8.51% | 0 | 0.00% | .044 |
| MIB2 | 4 | 8.51% | 0 | 0.00% | .044 |
| CENPF | 4 | 8.51% | 0 | 0.00% | .044 |
| SLC9A3 | 4 | 8.51% | 0 | 0.00% | .044 |
| DNAJC6 | 4 | 8.51% | 0 | 0.00% | .044 |
| MEI1 | 4 | 8.51% | 0 | 0.00% | .044 |
| ERN2 | 4 | 8.51% | 0 | 0.00% | .044 |
| PDE10A | 4 | 8.51% | 0 | 0.00% | .044 |
| ESYT2c | 4 | 8.51% | 0 | 0.00% | .044 |
| ZNF318 | 4 | 8.51% | 0 | 0.00% | .044 |
| CCDC166 | 4 | 8.51% | 0 | 0.00% | .044 |
| IQGAP3 | 4 | 8.51% | 0 | 0.00% | .044 |
| PAK7 | 4 | 8.51% | 0 | 0.00% | .044 |
| SCN8A | 4 | 8.51% | 0 | 0.00% | .044 |
| ANO7 | 4 | 8.51% | 0 | 0.00% | .044 |
| ARSI | 4 | 8.51% | 0 | 0.00% | .044 |
| NKPD1 | 4 | 8.51% | 0 | 0.00% | .044 |
| ASPHD1 | 4 | 8.51% | 0 | 0.00% | .044 |
| LAMB1 | 4 | 8.51% | 0 | 0.00% | .044 |
| ANP32E | 4 | 8.51% | 0 | 0.00% | .044 |
| ATXN2 | 4 | 8.51% | 0 | 0.00% | .044 |
| COL6A3 | 3 | 6.38% | 10 | 18.52% | .044 |
| FLNA | 0 | 0.00% | 7 | 12.96% | .014 |
| GTF2Ic,e | 0 | 0.00% | 7 | 12.96% | .014 |
| ZNF628e | 0 | 0.00% | 6 | 11.11% | .029 |
| MYOFe | 0 | 0.00% | 6 | 11.11% | .029 |
| MACF1 | 0 | 0.00% | 6 | 11.11% | .029 |
| RUBCNL | 0 | 0.00% | 6 | 11.11% | .029 |
| MUCL3 | 0 | 0.00% | 6 | 11.11% | .029 |
| CROCC2 | 0 | 0.00% | 6 | 11.11% | .029 |
a
Reconfirmed by Integrated Genomics Viewer.
b
Chi-squared test or the Fisher exact test.
c
In the samples with no cirrhosis, mutation frequencies differed between males and females.
d
In the samples with cirrhosis, mutation frequencies differed between males and females.
e
In the samples from patients with serum α-fetoprotein level less than 20 ng/mL, mutation frequencies differed between males and females.