Table 1. Eligibility criteria for the systematic review of outcomes used in the dementia with Lewy bodies literature.
Inclusion criteria | Exclusion criteria | |
---|---|---|
Publication year | • Any | |
Language | • No restriction for abstract screening | |
Types of articles | • Scientific articles
published in peer-reviewed journals with available full texts |
• Popular articles
• Editorials, commentaries etc. • Study protocols • Abstracts only • Conference abstracts • Trial registries |
Study design | • Comparative clinical trials
(regardless of randomization)
• Intervention trials with pre-/post assessments regardless of randomization, case reports |
• Observational studies
• Reviews, meta analysis (for further trials) |
Population/
Setting |
• People with dementia with
Lewy bodies (DLB) • 18 years and older; all sexes |
• Parkinson’s disease
(with and without mild cognitive impairment; PD-MCI) • Atypical parkinsonism (e.g., PPS, MSA) • Other dementias (e.g., AD, FTD) • Mixed study samples (e.g., Involving participants with different dementia subtypes) without separate reporting for Individuals with DLB |
Interventions | Any
pharmacological, surgical Or non-pharmacological approach for
treating motor and non-motor symptoms in Individuals with DLB at any disease stage and in any setting (e.g., outpatients as well as inpatients) |
|
Comparators | Any:
• None • Placebo/Passive control groups/Wait-list • Active control groups (comparison of different pharmacological/ surgical/non-pharmacological interventions) |
|
Outcomes | Any:
• Standardized quantitative assessments, including neurological examinations, assessments and tests, and questionnaires (self-and proxy-rating) across all domains, e.g.; ○ Disease severity, motor- and non-motor symptoms ○ Patient-Reported Outcome Measures (PROMs) including quality of life ○ Biomarkers, imaging outcomes ○ Changes in housing and care situation (e.g., institution) • Carer outcomes included in the patient targeted interventions will be considered (cf. Rigby 2021: https://pubmed.ncbi.nlm.nih.) gov/33554912/) • Qualitative approaches to evaluate intervention success across all domains (e.g., outcomes obtained through patient interviews, focus groups) • Economic evaluation outcomes (cost analysis, cost-effectiveness analysis, cost-utility analysis, cost-benefit analysis) |