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. 2022 Dec 22;12:22130. doi: 10.1038/s41598-022-25871-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunological landscape of immune cells from healthy subjects and patients with gout. (A) Study design. Immune cells extracted from (B) peripheral blood mononuclear cells (PBMCs) and (C) synovial fluid (SF) are presented in uniform manifold approximation and projection (UMAP) coordinates. (D) Bar chart of pain duration in patients with gout. Relative abundance of various cell subpopulations: (E) B cells; (F) T and NK cells; (G) a monocyte series including monocytes (Mono.), macrophages (Ma.), and dendritic cells (DCs); and (H) megakaryocytes, progenitor cells, low-density neutrophils, and low-density basophils.