Table 3.

In vitro inhibitory activities observed on the reaction catalyzed by MtSK between compounds with substituent halogens (chlorine and fluorine)

Compound	R1	R2	R3	Inhibitory activity (%)a
3b	F	F	H	23.83
5b	F	H	H	2.82
8b	H	H	F	–
9a	H	F	H	–
9b	H	H	H	–
3c	Cl	H	H	22.11
9c	H	Cl	H	10.11
9d	Cl	Cl	H	11.46
9e	H	H	Cl	–

^aAssigned with 50 μM final fixed concentrations of compounds in assay mixtures

– Non-detected inhibitory activity