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(A) The metabolic processes of tyrosine hydroxylase, tryptophan and phenylalanine clarify the pathogenesis of DRD and THD. (B) The sequence of proteins corresponding to missense mutation sites in different species. (C) TH missense mutation spectrum. Variant listed as red font was discovered in this report. (D) The three-dimensional atomic models based on TH protein sequence from wild type and mutation sites generated by iterative threading assembly refifinement server.
