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. 2022 Dec 20;10(12):e005655. doi: 10.1136/jitc-2022-005655

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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The sensitivity of anti-PD1 immunotherapy in HCC was increased in GSK3β ^fl/fl Lyz2 ^cre/+ mice. (A) Schematic diagram of establishment of mouse subcutaneous tumor model in each group. (B) Images of subcutaneous tumors in each group. (C, D) Analysis of subcutaneous tumors in the respective groups. (E, F) Immunohistochemistry results of CD8, Ki67, PD-L1 and PD1 expression in the respective groups. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. ns indicated no significant different. HCC, hepatocellular carcinoma.