TABLE 2.
Preclinical findings for 638T, 638T transformed with pVT1, and 638 in mice and rabbits
| Strain | Colonizationa (no. of vibrios)
|
Immune responseb
|
||||
|---|---|---|---|---|---|---|
| Vibriocidal antibody GMT (range) on day:
|
Anti- LPS IgG GMT (range) on day:
|
|||||
| Inoculated | Recovereda | 14 | 28 | 14 | 28 | |
| 638 | 5.9 × 106 | 1.5 × 106 | 800 (320–2,500) | 500 (320–1,200) | 150 (100–300) | 316 (200–400) |
| 638T | 1.0 × 106 | 3.0 × 105 | 485 (80–2,560) | 368 (80–1,280) | 355 (100–1,600) | 848 (100–3,200) |
| 638T/pVT1 | 3.6 × 106 | 1 × 106 | 640 (160–1,280) | 320 (160–640) | 640 (100–3,200) | 640 (100–3,200) |
a
Each value represents the average for at least eight mice from two independent experiments.
b
Each value represents the average for at least six rabbits. The day 0 titers were under 1:20 for vibriocidal antibodies and under 1:25 for anti-LPS IgG.