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. 2022 Apr 29;6(24):6162–6168. doi: 10.1182/bloodadvances.2022007031

Table 2.

Median change in laboratory values with respect to time (n = 135)

Baseline 3 mo 6 mo Median change in 3 mo (IQR) Median change in 6 mo (IQR) P P P P§
Hb, g/dL 6.5 (5.8-7.3) 8 (7.1-9.3) 8.7 (7.5-9.8) 1.6 (0.6-2.8) 2.3 (1-3.4) <.001 <.001 <.001 <.001
TLC 8.3 (6-11.7) 7.8 (6-10.6) 7.9 (5.8-11) 1.4 (0.6-3.4) 1.8 (0.7-3.6) .328 .097 .243 .548
Neutrophils 3.2 (2.4-4.4) 3 (2.1-4) 2.5 (2-3.8) 0.5 (0.3-1.2) 0.9 (0.5-1.7) <.001 .005 <.001 .009
Platelets 270 (186-405) 309 (237-429) 309 (237-429) 62 (29-136) 89 (35-191.5) .015 .002 .045 .377
Urea 20 (16-26) 20 (16-26) 5 (2-10) .764
Creatinine 0.4 (0.3-0.6) 0.3 (0.3-0.5) 0.1 (0.1-0.3) .206
Total bilirubin 1.7 (1.1-2.5) 1.6 (1.1-2) 0.7 (0.3-1.2) .122
Direct bilirubin 0.5 (0.4-1) 0.5 (0.4-0.8) 0.5 (0.3-1) .895
Indirect bilirubin 0.9 (0.4-1.4) 1.1 (0.6-1.4) 0.4 (0.1-0.7) .207
SGPT 35 (24-52) 40 (24-55) 14 (5-26) 156
Ferritin 912 (399.9-1660) 871 (400-1500) 208 (41-460) <.001
Liver size, cm 10 (9.3-12.2) 9.5 (9.1-12) 0.5 (0.1-1.1) .041
Spleen size, cm (n = 89) 9.8 (8.1-12.5) 9.6 (8-12) 0.7 (0.2-1.6) <.001

P ≤ .05 considered significant.

IQR, interquartile range; SGPT, serum glutamic pyruvic transaminase; TLC, total leukocyte count.

0, 3, and 6 mo (Friedman test).

0 and 3 mo (Wilcoxon signed-rank test).

0 and 6 mo (Wilcoxon signed-rank test).

§

3 and 6 mo (Wilcoxon signed-rank test).