Table 1.
Characteristics of the studies included in the meta-analysis.
| Studies | Jadad score (/5) | MYOINOSITOL group |
Control group |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Number (n) | Age (years (mean ± SD or (extrem values))) | BMI (kg/m2 (mean ± SD or (extrem values))) | Intervention | Number (n) | Age (years (mean ± SD or (extrem values))) | BMI (kg/m2 (mean ± SD or (extrem values))) | Intervention | ||
| D'Anna R 2012 (D'Anna et al., 2012) | 1 | 44 | 29.2 ± 3.8 | 26.2 ± 5.8 | MYO 2g + FA 200 μg 2/day | 54 | 30.6 ± 4.2 | 24.7 ± 3.9 | FA 200 μg 2/day |
| D'Anna R 2013 (D'Anna et al., 2013) | 3 | 110 | 31.0 ± 5.3 | 22.8 ± 3.1 | MYO 2g + FA 200 μg 2/day | 110 | 31.6 ± 5.6 | 23.6 ± 3.1 | FA 200 μg 2/day |
| Matarelli 2013 (Matarrelli et al., 2013) | 3 | 39 | 33.0 ± 4.9 | 23.5 ± 3.4 | MYO 2g + FA 200 μg 2/day | 36 | 33.8 ± 4.7 | 24.7 ± 42 | FA 200 μg 2/day |
| D'Anna R 2015 (D'Anna et al., 2015) | 3 | 110 | 31.9 (18-44) | 33.8 (30.0-46.9) | MYO 2g + FA 200 μg 2/day | 110 | 31.7 (19-43) | 33.8 (30.0-46.0) | FA 200 μg 2/day |
| Santamaria et al., 2016 (Santamaria et al., 2016) | 3 | 110 | 32.1 ± 4.8 | 26.9 ± 1.3 | MYO 2g + FA 20 μg 2/day | 110 | 32.7 ± 5.3 | 27.1 ± 1.3 | FA 200 μg 2/day |
| Farren et al., 2017 (Farren et al., 2017) | 3 | 120 | 31.1 ± 5.1 | 26.0 ± 5.3 | MYO 1100 mg + DCI 27.6 mg + FA 400 μg 1/day | 120 | 31.5 ± 5.0 | 26.2 ± 5.5 | FA 400 μg 1/day |
| D'Ell Edera 2017 (Dell’Edera et al., 2017) | 2 | 43 | 32.5 ± 3.6 | 25.6 ± 4.0 | MYO 1750 mg + DCI 250 mg + zinc 12,5 mg + methylsulfonylmethane 1/day | 40 | 32.3 ± 3.8 | 26.9 ± 3.1 | FA 400 μg 1/day |
| Celentano et al., 2020 (Celentano et al., 2020) | 3 | 60 | 33.1 ± 4.9 | 23.5 ± 3.4 | MYO 2g + FA 200 μg 2/day | 40 | 33.9 ± 4.9 | 24.4 ± 4.1 | FA 200 μg 2/day |
| 40 | 34.1 ± 4.2 | 23.5 ± 4.6 | MYO 1100 mg + DCI 27.6 mg + FA 400 μg 1/day | ||||||
| Vitale 2020 (Vitale et al., 2021) | 3 | 125 | 27.8 ± 6.0 | 27.0 ± 1.5 | MYO 2g + FA 200 μg 2/day | 125 | 27.9 ± 4.9 | 26.7 ± 1.6 | FA 200 μg 2/day |
BMI: body mass index; d: day; DCI: 1D-chiro-inositol; FA: folic acid; MYO: myoinositol; SD: standard deviations.