Fig. 11.

TME and TIME analysis based on CRLncs-score. (A) Differential analysis of tumor microenvironment by ESTIMATE algorithm. (B). Inferred CAF proportion scores of OS patients by four algorithms (see Methods). EPIC, MCP-Counter, xCell, and TIDE indicated the assumed CAF proportion. The stroma score (A) and CAFs(B) were significantly higher in the low-risk group. Immune cell(C) and immune function(D) differential analysis were shown using ssGSEA algorithms. (E) Selecting suitable targeting drugs for different risk- groups of patients.