Figure 3.

Relative comparison of normative reductions of acetylcholinesterase hydrolysis rate versus proxy blood flow changes in the baseline Parkinson’s disease group. Z-scores based on comparison with normative data are presented. Relative comparison of Z(k₃) to Z(k₁) scores show striking topographic dissociation between vulnerability of cholinergic losses in Parkinson’s disease compared with more prominent k₁ proxy blood flow reductions, in particular the superior and posterior parietal and anterior and inferior prefrontal cortices and reverse findings of relatively more prominent cholinergic reductions in the primary sensorimotor strip.