Table 1.

Univariate and multivariate Cox analysis according to OS integrating CD8+ T cells, macrophages, gender, age, clinical stage, T stage, N stage, M stage.

Characteristics	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age	1.02 (1.01-1.04)	<.001	1.03 (1.02-1.04)	<.001
Gender
Female	Reference
Male	0.76 (0.57-1.03)	.07
Clinical stage
Stage I	Reference
Stage II & Stage III & Stage IV	1.11 (0.95-1.30)	.19
T stage
T1	Reference
T2 & T3 & T4	1.10 (0.95-1.27)	.22
N stage
N0	Reference
N1 & N2 & N3	1.18 (1.01-1.37)	.04	1.23 (1.05-1.44)	<.01
M stage
M0	Reference
M1	4.50 (1.66-12.23)	<.01	6.73 (2.73-18.64)	<.001
Histologic grade
G1	Reference
G2 & G3 & G4	1.10 (0.89-1.36)	.37
CD8 T	0.01 (0.001-0.08)	<.001	0.003 (0.0003-0.03)	<.001
Macrophage	6.23 (1.10-35.42)	.04	3.97 (0.70-22.35)	.12