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. 2022 Nov 25;49(1):16. doi: 10.3892/or.2022.8453

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Overexpression of GPX4 reverses the effects of silencing of SND1 on the sensitivity of BC cells to cisplatin. (A) T24/R and 5637/R cells were transfected as indicated for 24 h, and the mRNA levels of GPX4 were determined. (B) The protein levels of GPX4 were assessed. (C) T24/R and 5637/R cells were treated as indicated, and the cellular viabilities were detected. (D) Cellular death was assessed. (E) The reactive oxygen species levels were determined. (F) Th iron levels were detected. (G) The glutathione levels were assessed. (H) Malondialdehyde levels were determined. Data are presented as the mean ± standard deviation. *P<0.05 and **P<0.01. GPX4, glutathione peroxidase 4; SND1, staphylococcal nuclease and tudor domain containing 1; BC, bladder cancer; sh, short hairpin RNA; NC, negative control; EV, empty vector; OV, overexpression; ROS, reactive oxygen species; GSH, glutathione; MDA, malondialdehyde.