Table 5.
Hematology values for male and female rats administered N. crassa biomass via gavage twice daily for 13 weeks.
| Parameters measureda | XX dose group (mg/kg) | |||||||
|---|---|---|---|---|---|---|---|---|
| Males | Females | |||||||
| 0 (control) (n = 10) | 1000 (n = 10) | 2500 (n = 8) | 5000 (n = 8) | 0 (control) (n = 10) | 1000 (n = 9) | 2500 (n = 10) | 5000 (n = 9) | |
| Hematology | ||||||||
| Basophils[a] (x103/μL) | 0.112 ± .053 | 0.126 ± .054 | 0.146 ± .080 | 0.223 ± .089* | 0.107 ± .034 | 0.103 ± .062 | 0.147 ± .063 | 0.099 ± .021 |
| Eosinophils[a1] (x103/μL) | 0.044 ± .036 | 0.055 ± .025 | 0.081 ± .039 | 0.099 ± .042** | 0.064 ± .039 | 0.061 ± .028 | 0.061 ± .031 | 0.068 ± .014 |
| LUC (x103/μL) | 0.084 ± .048 | 0.057 ± .036 | 0.060 ± .028 | 0.058 ± .035 | 0.032 ± .018 | 0.026 ± .010 | 0.052 ± .028 | 0.038 ± .012 |
| Lymphocytes (x103/μL) | 7.705 ± 2.287 | 6.318 ± 2.353 | 7.066 ± 1.813 | 8.375 ± 2.599 | 4.086 ± 1.697 | 3.744 ± .804 | 4.736 ± 1.021 | 4.341 ± 1.457 |
| Monocytes (x103/μL) | 0.459 ± .165 | 0.301 ± .126 | 0.351 ± .150 | 0.330 ± .096 | 0.183 ± .093 | 0.213 ± .129 | 0.231 ± .094 | 0.158 ± .047 |
| Neutrophils (x103/μL) | 2.129 ± .888 | 2.008 ± .665 | 2.714 ± 1.455 | 2.153 ± .373 | 1.235 ± .323 | 1.474 ± .656 | 1.521 ± .499 | 1.234 ± .629 |
| Reticulocyte (x103/μL) | 162.440 ± 22.742 | 178.450 ± 33.182 | 179.538 ± 37.577 | 151.138 ± 32.826 | 157.410 ± 36.434 | 167.389 ± 21.713 | 159.180 ± 23.647 | 159.922 ± 2.819 |
| Hematocrit[a2], [a1] (%) | 44.94 ± 1.63 | 45.82 ± 3.40 | 47.51 ± 1.02** | 48.14 ± .93*** | 43.05 ± 1.31 | 44.48 ± 1.50 | 45.79 ± 1.00 | 45.17 ± 1.52 |
| Hemoglobin[a2],[a1] (g/dL) | 14.09 ± .46 | 14.36 ± 1.17* | 15.11 ± .25*** | 15.50 ± .30*** | 13.60 ± .50 | 14.11 ± .38* | 14.53 ± .30*** | 14.44 ± .50*** |
| MCV (fL) | 55.35 ± 1.59 | 56.21 ± 2.26 | 56.89 ± 2.33 | 55.30 ± 1.11 | 54.67 ± 1.90 | 55.90 ± .77 | 56.41 ± 1.61 | 56.13 ± 1.87 |
| MCH (pg) | 17.40 ± .49 | 17.62 ± .81 | 18.11 ± .99 | 17.80 ± .40 | 17.32 ± .66 | 17.74 ± .30 | 17.90 ± .47 | 17.93 ± .58 |
| MCHC[a1] (g/dL) | 31.43 ± .36 | 31.31 ± .48 | 31.80 ± .58 | 32.20 ± .44** | 31.59 ± .44.35 | 31.74 ± .58 | 31.72 ± .35 | 32.01 ± .47 |
| Platelets (x103/μL) | 76.90 ± 131.32 | 516.10 ± 326.38 | 69.63 ± 269.35 | 814.25 ± 283.42 | 923.80 ± 54.75 | 882.00 ± 203.14 | 885.70 ± 16.31 | 904.11 ± 127.46 |
| RBC[a2] (x106/μL) | 8.110 ± .287 | 8.156 ± .615 | 8.360 ± .396 | 8.704 ± .211*** | 7.878 ± .325 | 7.958 ± .236 | 8.128 ± .333 | 8.054 ± .307 |
| RDW[a1] (%) | 14.93 ± .38 | 14.77 ± .34 | 14.79 ± .34 | 14.43 ± .41* | 11.90 ± .39 | 11.54 ± .25* | 11.49 ± .34* | 11.47 ± .22* |
| WBC (x103/μL) | 1.535 ± 3.115 | 8.867 ± 2.726 | 1.419 ± 3.197 | 11.238 ± 2.602 | 5.686 ± 1.920 | 5.643 ± 1.334 | 6.749 ± 1.438 | 5.939 ± 1.391 |
ANOVA = analysis of variance; LUC = large unstained cells; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; MCV = mean corpuscular volume; RBC = red blood cells; RDW = red cell distribution width; WBC = white blood cells.
Values represent the mean ± standard deviation.
aStatistical tests are indicated in square brackets for each parameter. If two different tests were used for males and females, the footnotes are separated by a comma.
[a]Statistically significant (* = p < .05; ** = p < .01) using ANOVA and Dunnett’s (log) two-sided test.
[a1]Statistically significant (* = p < .05; ** = p < .01; *** = p < .001) using ANOVA and Dunnett’s two-sided test.
[a2]Statistically significant (* = p < .05; ** = p < .01; *** = p < .001) using ANOVA and Dunnett’s (rank) two-sided test.