Table 1.
Current ongoing CAR T therapy clinical trials in solid tumors.
| Target | Clinical trial number | Treatment | Cancer types | Region |
|---|---|---|---|---|
| MSLN | NCT05373147 | αPD1-MSLN CAR-T | Solid Tumor | China |
| NCT05531708 | MSLN-CAR T | Mesothelin-positive Advanced Refractory Solid Tumors | China | |
| NCT05166070 | MSLN-CAR T | Solid Tumor | ||
| NCT04489862 | αPD1-MSLN-CAR T | Non-small-cell Lung Cancer | China | |
| Mesothelioma | ||||
| NCT05141253 | MSLN-CAR T | MSLN-positive solid tumors | China | |
| NCT04981691 | MSLN-CAR T | Refractory Malignant Solid Neoplasm | China | |
| Claudin 18.2 | NCT05583201 | Claudin 18.2 CAR-T | Gastric Cancer | China |
| Pancreatic Cancer | ||||
| Solid Tumor | ||||
| NCT05472857 | Claudin 18.2 CAR-T | Gastric Cancer | China | |
| Pancreatic Cancer | ||||
| Advanced Ovarian Carcinoma | ||||
| Gastroesophageal Junction Adenocarcinoma | ||||
| NCT03874897 | Claudin 18.2 CAR-T | Advanced Solid Tumor | china | |
| PD-1 Monoclonal Antibody | ||||
| Chemotherapy | ||||
| NCT04467853 | Claudin 18.2 CAR-T | Solid Tumors | China | |
| NCT05275062 | Claudin 18.2 CAR-T | Advanced Solid Tumors | China | |
| Gastric Cancer | ||||
| Esophagogastric Junction Cancer | ||||
| Pancreatic Cancer | ||||
| NCT05199519 | Claudin 18.2 CAR-T | Solid Tumor | China | |
| NCT04581473 | Claudin 18.2 CAR-T | Gastric Adenocarcinoma | China | |
| Pancreatic Cancer | ||||
| Gastroesophageal Junction Adenocarcinoma | ||||
| CLDN6 | NCT04503278 | CLDN6 CAR-T | Solid Tumor | Germany |
| NKG2D | NCT05583201 | NKG2D/CLDN18.2 CAR-T | Gastric Cancer | China |
| Pancreatic Cancer | ||||
| Solid Tumor | ||||
| NCT05382377 | NKG2D CAR-T | CRC | China | |
| Solid Tumor | ||||
| NCT05131763 | NKG2D CAR-T | Hepatocellular Carcinoma | China | |
| Glioblastoma | ||||
| Medulloblastoma | ||||
| Colon Cancer | ||||
| GD2 | NCT05437315 | GD2/PSMA CAR-T | Solid Tumor | China |
| NCT03373097 | GD2 CAR-T | Neuroblastoma | Italy | |
| Neuroblastoma Recurrent | ||||
| GD2-positive Solid Tumors | ||||
| (and 3 more...) | ||||
| NCT01822652 | GD2 CAR-T | Neuroblastoma | United States | |
| Drug: Cytoxan | ||||
| Nectin4/FAP | NCT03932565 | Nectin4/FAP CAR-T | Nectin4-positive Advanced Malignant Solid Tumor | China |
| CD22 | NCT04556669 | aPD-L1 armored CD22 CAR-T | Solid Tumor, Adult | China |
| Cervical Cancer | ||||
| Sarcoma | ||||
| NSCLC | ||||
| CD70 | NCT05518253 | CD70 CAR-T | Metastatic Tumor | China |
| Advanced Solid Tumor | ||||
| Renal Cell Carcinoma | ||||
| (and 2 more...) | ||||
| NCT05420545 | CD70 CAR-T | Metastatic Tumor | China | |
| Advanced Solid Tumor | ||||
| Renal Cell Carcinoma | ||||
| (and 2 more...) | ||||
| NCT05468190 | CD70 CAR-T | Metastatic Tumor | China | |
| Advanced Solid Tumor | ||||
| Renal Cell Carcinoma | ||||
| (and 2 more...) | ||||
| HER-2 | NCT04650451 | HER-2 CAR-T | HER-2 Gene Amplification | United States |
| HER2-positive Gastric Cancer | ||||
| HER2-positive Breast Cancer | ||||
| (and 2 more...) | ||||
| NCT03740256 | CAdVEC | Bladder Cancer | United States | |
| HER-2 CAR-T | Head and Neck Squamous Cell Carcinoma | |||
| Cancer of the Salivary Gland | ||||
| (and 7 more...) | ||||
| NCT04511871 | HER-2 CAR-T | Solid Tumor | China | |
| Gastric Cancer | ||||
| Breast Cancer | ||||
| (and 2 more...) | ||||
| NCT03618381 | CD19-HER2 CAR-T | Pediatric Solid Tumor | United States | |
| EGFR CAR-T | Germ Cell Tumor | |||
| Retinoblastoma | ||||
| (and 13 more...) | ||||
| EGFR | NCT04483778 | B7H3-EGFR CAR-T | Pediatric Solid Tumor | United States |
| CD19-HER2 CAR-T | Germ Cell Tumor | |||
| Retinoblastoma | ||||
| (and 14 more...) | ||||
| NCT04976218 | EGFR CAR-T | Solid Tumor, Adult | China | |
| EGFR Overexpression | ||||
| NCT05341492 | EGFR/B7H3 CAR-T | EGFR/ B7H3-positive Advanced Lung Cancer | China | |
| EGFR/ B7H3-positive Advanced Triple-negative Breast Cancer | ||||
| NCT03618381 | CD19-HER2 CAR-T | Pediatric Solid Tumor | United States | |
| EGFR CAR-T | Germ Cell Tumor | |||
| Retinoblastoma | ||||
| (and 13 more...) | ||||
| VEGFR1 | NCT05477927 | VEGFR1/PD-L1 CAR-T | Malignant Peritoneal Effusion | China |
| Malignant Ascites | ||||
| Serous Cavity Metastatises | ||||
| EpCAM | NCT02915445 | EpCAM CAR-T | Malignant Neoplasm of Nasopharynx TNM Staging Distant Metastasis (M) | China |
| Breast Cancer Recurrent | ||||
| Gastric Cancer With Metastasis | ||||
| CEA | NCT05415475 | CEA CAR-T | Colorectal Cancer | China |
| Esophageal Cancer | ||||
| Stomach Cancer | ||||
| (and 3 more...) | ||||
| NCT05396300 | CEA CAR-T | Colorectal Cancer | China | |
| Esophageal Cancer | ||||
| Stomach Cancer | ||||
| (and 3 more...) | ||||
| NCT05538195 | CEA CAR-T | Gastric Cancer | China | |
| Colon Cancer | ||||
| Rectal Cancer | ||||
| (and 2 more...) | ||||
| NCT04348643 | CEA CAR-T | Solid Tumor | China | |
| Lung Cancer | ||||
| Colorectal Cancer | ||||
| (and 4 more...) | ||||
| B7-H3 | NCT04897321 | B7-H3 CAR-T | Pediatric Solid Tumor | United States |
| Cyclophosphamide | Osteosarcoma | |||
| MESNA | Rhabdomyosarcoma | |||
| Fludarabine | (and 13 more...) | |||
| NCT05341492 | GFR/B7-H3 CAR-T | EGFR/ B7H3-positive Advanced Lung Cancer | China | |
| EGFR/ B7H3-positive Advanced Triple-negative Breast Cancer | ||||
| NCT04483778 | B7H3-EGFR CAR-T | Pediatric Solid Tumor | United States | |
| CD19-HER2 CAR-T | Germ Cell Tumor | |||
| Retinoblastoma | ||||
| (and 14 more...) | ||||
| NCT05190185 | B7-H3 CAR-T | Malignant Melanoma | China | |
| Lung Cancer | ||||
| Colorectal Cancer | ||||
| Glypican-3 | NCT04377932 | Glypican-3 CAR-T | Liver Cancer | United States |
| Cytoxan | Rhabdomyosarcoma | |||
| Fludara | Malignant Rhabdoid Tumor | |||
| (and 3 more...) | ||||
| NCT02932956 | Glypican-3 CAR-T | Liver Cancer | United States | |
| Cytoxan | ||||
| Fludara | ||||
| ROR2 | NCT03960060 | ROR2 CAR-T | Solid Tumor | China |
| Soft Tissue Sarcoma | ||||
| Gastric Cancer | ||||
| (and 2 more...) | ||||
| ROR1 | NCT05274451 | ROR1 CAR-T | Triple Negative Breast Cancer | United States |
| TNBC - Triple-Negative Breast Cancer | ||||
| Non-small Cell Lung Cancer | ||||
| (and 12 more...) | ||||
| MUC1 | NCT05239143 | P-MUC1C-ALLO1 CAR-T | Breast Cancer | United States |
| Rimiducid | Ovarian Cancer | |||
| Non Small Cell Lung Cancer | ||||
| (and 6 more...) | ||||
| NCT04025216 | TnMUC1 CAR-T | Non-Small Cell Lung Cancer | United States | |
| Cyclophosphamide | Ovarian Cancer | |||
| Fludarabine | Fallopian Tube Cancer | |||
| (and 3 more...) | ||||
| MUC16 | NCT02498912 | MUC16 CAR-T | Solid Tumors | United States |
| PSCA | NCT02744287 | PSCA CAR-T | Metastatic Castration-resistant Prostate Cancer | United States |
| Metastatic Prostate Cancer | ||||
| GUCY2C | NCT05287165 | GUCY2C CAR-T | Advanced Solid Tumors | China |
| Digestive System Neoplasms | ||||
| Pancreatic Cancer Resectable | ||||
| Colorectal (Colon or Rectal) Cancer | ||||
| GPC3 | NCT05120271 | GPC3 CAR-T | Hepatocellular Carcinoma | United States |
| Squamous Cell Carcinoma of the Lung | ||||
| Merkel Cell Carcinoma | ||||
| Myxoid/Round Cell Liposarcoma |