TABLE 3.
Responses to inoculation of live H. ducreyi strainsa
| Subject no. | Observation period (days) | Isolate | No. of initial papules | Final outcome of initial papule
|
||
|---|---|---|---|---|---|---|
| No. of papules | No. of pustules | No. resolved | ||||
| 134 | 14 | |||||
| 35000HP | 2 | 1 | 1 | |||
| 35000HP-SMS4 | 3 | 1 | 2 | |||
| 135 | 14 | |||||
| 35000HP | 2 | 1 | 1b | |||
| 35000HP-SMS4 | 2 | 1c | 1 | |||
| 136 | 6 | |||||
| 35000HP | 2 | 2 | ||||
| 35000HP-SMS4 | 3 | 3 | ||||
| 139 | 9 | |||||
| 35000HP | 2 | 1 | 1 | |||
| 35000HP-SMS4 | 2 | 2 | ||||
| 140 | 12 | |||||
| 35000HP | 2 | 2 | ||||
| 35000HP-SMS4 | 3 | 3 | ||||
| 141 | 7 | |||||
| 35000HP | 2 | 2 | ||||
| 35000HP-SMS4 | 3 | 2 | 1 | |||
| 144 | 8 | |||||
| 35000HP | 2 | 2 | ||||
| 35000HP-SMS4 | 3 | 3 | ||||
| 145 | 14 | |||||
| 35000HP | 2 | 2b | ||||
| 35000HP-SMS4 | 3 | 3 | ||||
| 147 | 7 | |||||
| 35000HP | 2 | 1 | 1 | |||
| 35000HP-SMS4 | 3 | 3 | ||||
a
Each volunteer was inoculated at two sites with 35000HP and at three sites with 35000HP-SMS4. Volunteers 134 to 136 were inoculated in the first iteration, volunteers 139 to 141 were inoculated in the second iteration, and volunteers 144, 145, and 147 were inoculated in the third iteration.
b
Pustules formed at three parent-inoculated sites but resolved by day 12 or 14.
c
A pustule formed at one mutant-inoculated site but reverted to a papule by day 12.