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. 2022 Dec 6;7(50):45797–45809. doi: 10.1021/acsomega.2c04708

Table 2. Plants Used in Herbal Cigarettes, Major Active Constituents, and Health Benefits and Hazards.

herb major active constituent health benefits upon inhalation health hazards reference
spreading dogbane (Apocynum venetum) volatile oils (fatty acids, aldehydes, ketones, esters, alkanes, and phenols) detoxifying nicotine when used with tobacco no severe side effects (13, 34)
    sedative effect    
mugwort (Artemisia vulgaris) mono/sesquiterpenes (eucalyptol, camphor, linalool, thujone, 4-terpineol, borneol, α-cadinol, spathulenol) smoke reduces heart rate and stress and improves the autonomic nervous system allergic for the respiratory system and skin, causing dermatitis (13, 48, 49, 7174)
    decreases pain and depression and improves ego integrity    
Tu-chung (Eucommia ulmoides) volatile oils (aldehydes, furans, alkenes, alkanes, ketones, aromatic compounds, ethers, and esters) aroma induces hypnotic effect; leaf extract inhalation improves sleeping and prevents insomnia progression no signs of toxicity, mutagenicity, or immunotoxicity (75, 76)
clove (Syzygium aromaticum) eugenol reduces noxious elements of smoking; smoking cloves relieves asthmatic symptoms hemoptysis, bronchospasm, hemorrhagic and nonhemorrhagic pulmonary edema, pleural effusion, respiratory insufficiency, respiratory infection, and aspiration (61, 62, 7779)
Devil’s Trumpet (Datura stramonium) alkaloids (hyoscyamine and atropine) calming effect in schizoid patients anticholinergic syndrome including dry skin, flushing, blurred vision, altered mental status, tachycardia, urinary retention, seizures, coma, and respiratory failure (67, 80, 81)
    powerful mind-altering drug    
lavender (Lavandula angustifolia) volatile oils (linalyl acetate, β-linalool, and β-caryophyllene) antianxiety, relaxing, and mood-control effects some adverse effects occurred with patients receiving lavender aromatherapy (55, 82, 83)
    decreases blood pressure, heart rate, and skin temperature    
    aromatherapy using lavender oil proved successfulness and safety in many cases, especially in reducing pain    
samiana (Turnera diffusa) sesquiterpenes, copaene, 1,8-cineol, γ-muurolene, oplopenone, cubebol, cubenol, δ-cadinene, nerolidol, thymol, germacrene d-4-ol, caryophyllene oxide, ledol, anethole, β-eudesmol, and juniper camphor CNS psychoactive and aphrodisiac long-term use can lead to inflammations of the liver and tetaniform convulsions (3941)
mullein (Verbascum thapsus L.) volatile oils obtained from the dried flowering aerial parts (6,10,14-trimethyl-2-pentadecanone and (E)-phytol) assists in asthma, coughs, bronchitis, and whooping cough studies proved that phytol is not considered a significant contributor to the PAHs formation in cigarette smoke (43, 84, 85)
    burning its dried leaves and inhaling its smoke can help with asthma attacks    
coltsfoot (Tussilago farfara) sesquiterpene (tussilagone) potent respiratory and cardiac stimulant, inhaling the steam from the leaves and flowers soothes bronchitis and helps in shortness of breath deep vein thrombosis is possibly associated with the use of coltsfoot together with symptomatic pulmonary embolism (45, 86, 87)