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Pathogenesis of transthyretin cardiac amyloidosis a) Transthyretin is produced in the liver as a tetrameric protein b) The tetramer dissociates into monomer subunits c) The monomers misfolds and reaggregates into toxic dimers and oligomers and insoluble amyloid fibrils d) The amyloid fibrils get deposited extracellularly in the interstitial space of the myocardium.
