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. 2022 Dec 6;7(50):45882–45909. doi: 10.1021/acsomega.2c05852

Table 2. Methylene Blue (MB)-Based Nanocomposite Systems Used for Cancer Therapy.

nanocomposites (NCs) PS laser parameter size (nm) zeta potential (mV) cancer cell line application ref
methylene blue (MB) with/without gold or silver NPs MB NIR (660 nm; 25 W/cm2) 21 nm, 43 nm –48 mV MDA-MB-468 breast cancer (PDT) (224)
methylene blue-liposome MB NIR (660 nm; 165 mW/cm2) 140 nm not defined 4T1 breast cancer (PDT) (130)
graphene oxide-methylene blue NCs MB red light LED irradiation 20 nm not defined MDA-MB-231 breast cancer (PDT) (225)
MB and veliparib NPS (VMB-NPs) MB 660 nm(102 J/cm2) 90 nm –3.7 mV B16F10-Nex2 cells skin cancer (PDT) (226)
sulfur-doped graphene quantum dot and methylene blue preparations (GQD:MB) MB 660 nm, 12 W >20 nm not defined MCF-7 cells breast cancer (PDT) (227)
methylene blue and curcumin Ion-pair NPs MB (red LED 630 nm; 30 mW/cm2); blue LED (465 nm; 34 mW/cm2) 40–60 nm not defined MDA-MB-231 breast cancer (PDT) (228)
methylene blue: salicylic acid (SA-MB) MB NIR (630 nm; 30 mW/cm2) not defined not defined MDA-MB-231 breast cancer (PDT) (229)
MB-PDT MB 660 nm not defined not defined not defined skin cancer (PDT) (230)
GGH@AuNRs/MB hydrogel (Gellan Gum, Ca2+, gold nanorods (AuNRs) and methylene blue (MB) MB 808 nm laser at 0.5 W/cm2; 660 nm laser at 50 mW/cm2 not defined 33.1 mV HeLa cells, 3T3 cells and MCF-7 cells Henrietta’s cancer, breast cancer (PDT–PTT) (231)
GO-MB/PF127 nanocomposite MB 808 nm laser at 0.5 W/cm2; 660 nm laser at 50 mW/cm2 121.8 nm –16.70 mV HL-7702 cells and SiHa cells skin cancer (PDT–PTT) (232)