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. 2022 Dec 6;7(50):45882–45909. doi: 10.1021/acsomega.2c05852

Table 3. Chlorin-Based Nanocomposite Systems Used for Cancer Therapy.

nanocomposites (NCs) PS laser parameter size (nm) zeta potential (mV) cancer cell line application ref
CM/SLN/Ce6 NPs silica NPs (SLN) with cell membrane (CM) Ce6 680 nm laser, (1 W/cm2) 90.4 ± 3.2 nm +32.4 ± 1.7 mV SGC7901 cells gastric cancer (PDT) (233)
SWCNTs-HA-Ce6 (single-walled carbon nanotubes, hyaluronic acid (HA) and chlorin e6 (Ce6) Ce6 660 nm laser (5 and 10 J/cm2) 203 ± 6.6 nm –18.9 ± 1 mV Caco-2 cells colon cancer (PDT) (234)
Ce6-Fu/AL@GG-based hydrogel (Chlorin e6 (Ce6)-fucoidan/alginates@gellam gum) Ce6 660 nm laser (4 J/cm2) not defined not defined HT-29 cells colon cancer (PDT) (235)
Ce6-PDT Ce6 650 nm, (4 J/cm2) not defined not defined SW620 cells colon cancer (PDT) (236)
GNPs@PEG/Ce6-human PD-L1 peptide nanoprobes gold NPS(GNPs) Ce6 633 nm, (0.8 W/cm2) >100 nm –11.38 ± 3.89 mV HCC827 and A549 cells lung cancer (PDT–PTT) (237)
Ce6/Dox@NPs-cRGD (CDNR NPs) Cyclo(Arg-Gly-Asp-d-Phe-Cys) (c(RGDfC), cRGD) Ce6 670 nm laser (0.25 W/cm2) 112.6 nm –21.5 mV MCF-7 cells breast cancer (PDT) (238)
CNPs-Ce6, Ce6 loaded chitosan NPs (CNPs) Ce6 635 nm laser (50 mW/cm2) 160–200 nm 24.77 mV A549 cells lung cancer (PDT) (239)
G-chlorin e6 (glucose-conjugated chlorin e6) Ce6 664 nm laser (100 J/cm2) (150 mW/cm2). not defined not defined MKN45 cells and HT29 cells gastrointestinal cancer (PDT) (240)
Ce6 mediated PDT Ce6 690 nm NIR laser irradiation (0.5 w/cm2) not defined not defined Lewis cells lung cancer (PDT) (241)
Ce6 and IgG nanocomplexes (Chlorin e6 + immunoglobulin G) Ce6 660 nm (80 mW/cm2) ∼7 and ∼44 nm not defined GL261, a PD-L1 positive cell line glioma (PDT) (242)